Neurodegenerative disorders

Neurodegenerative disorders are conditions in which nerve cells of the brain and/or spinal cord breaks down and die which over time will lead to neurological symptoms and dysfunctions.

The brain and spinal cord (the Central Nervous System) are composed of nerve cells with different function such as controlling skilled movements, processing sensory information, storage of information and making decisions. Cells of the brain and spinal cord do not usually regenerate, so damage to the nervous system can be devastating. Normally, the neurodegenerative process in the Central Nervous System begins long before any symptoms appear. Neurodegenerative diseases result from deterioration of nerve cells, which over time will lead to dysfunctions.

Protein misfolding

The last decades the knowledge of neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease has moved from description of symptoms to a disease mechanistic understanding on a molecular level. The key molecular events in these diseases are today believed to be protein misfolding and spreading of soluble protein aggregates that lead to neuronal dysfunction, cell death, brain damage and symptoms of disease.

Each neurodegenerative disease is characterized by its unique aggregated protein. The hallmark of Alzheimer’s disease is the protein amyloid-beta, whereas alpha-synuclein is the signature protein of Parkinson’s disease.

Affect the lives of millions

Neurodegenerative diseases affect the lives of millions and lead to a growing public health challenge with increased costs for individuals and society. Most of these disorders increase with age. The lack of effective treatments that can halt or delay the disease progression is a huge medical problem. The prevention and treatment of these neurodegenerative disorders represent a critical goal of medical research today.

BioArctic is committed to help people with neurodegenerative diseases and to improve the future for people with Alzheimer’s disease, Parkinson’s disease and other neurodegenerative diseases through innovative research and development.

Today, there are neither cures nor effective treatments that affect the underlying cause of these devastating diseases.