Novel treatments to help patients with central nervous system disorders

Neurodegenerative disorders

Neurodegenerative disorders are conditions in which cells of the brain and/or spinal cord degenerate and die. The brain and spinal cord are composed of neurons with different functions such as controlling skilled movements, processing sensory information, storage of information and making decisions. Cells of the brain and spinal cord do not usually regenerate, so damage to the nervous system can be devastating. Normally, the neurodegenerative process begins long before any symptoms appear. Neurodegenerative diseases result from deterioration of neurons, which over time will lead to dysfunction and disabilities.

Neurodegenerative diseases markedly affect the lives of millions and lead to a growing public health challenge with increased costs for individuals and society. The prevention and treatment of these neurodegenerative disorders represent a critical goal of medical research today. Most of these disorders increase with age. Today, there are 46 million suffering from dementia and it is generally believed that there will be 130 million demented persons by 2050. The lack of effective treatments that can halt or reverse the disease process indicates a huge medical need.

In recent years the knowledge of these disorders has moved from description of symptoms to a mechanistic understanding on a molecular level. The key molecular events in these diseases are today believed to be protein misfolding and spreading of soluble protein aggregates that lead to neuronal dysfunction, cell death, brain damage and symptoms of disease. Each neurodegenerative disease is characterised through its unique aggregated protein. An attractive treatment strategy is to inactivate these toxic proteins.

Today, there are neither cures nor effective treatments that consistently slow or halt the course of these devastating neurodegenerative diseases. BioArctic is committed to bring hope to people with neurodegenerative diseases and to change the future for people with Alzheimer’s, Parkinson’s and other neurodegenerative diseases through innovative research.